What to Expect at the 5th ADC Analytical Development Summit?
The 5th ADC Analytical Development Summit is designed to equip you and your team with the strategies needed to overcome the current challenges and ensure a high quality, regulatory-compliant ADC product. Join 80+ senior analytical scientists, CMC leaders, and quality experts from leading organizations for three days of unparalleled insight and connection in Boston.
The agenda has been created to help you decipher complex heterogeneity by exploring advanced strategies to move beyond average DAR and control full drug load distribution. It also addresses how to navigate novel degradation pathways and impurities arising from next-generation linkers and payloads.
You will gain practical guidance on designing biologically relevant bioassays for bispecific and dual-payload ADCs. The program also focuses on overcoming critical hurdles in transferring complex cell-based and analytical methods to CDMOs and QC laboratories, while navigating the regulatory landscape to construct compelling CMC narratives.
With 22+ expert-led case studies from analytical scientists and senior decision makers at AbbVie, Pfizer, AstraZeneca, Merck, and more, alongside 3 dedicated pre-conference workshops, you will gain the technical depth needed to optimize physicochemical, potency, and impurity analytical methods. This will enable effecting DAR assessment and support robust regulatory submissions for your ADC products.
Unmissable Event Highlights:
Decipher Invisible Heterogeneity
Push beyond average DAR with native MS, 2D-LC/MS, and orthogonal methods to fully resolve and control the complete drug load distribution for unprecedented product understanding, with Pfizer & Merck
Master Impurity Control for Novel Linkers
Uncover and quantify unknown degradation products from next-gen payload-linkers using small molecule elucidation tools (HR-MS, NMR) to set scientifically justified specifications and de-risk stability, with Bristol Myers Squibb
Prove Dual-Target Engagement
Deconstruct the complex mechanism of action for bispecific and dual-payload ADCs to design robust, biologically relevant bioassays that accurately reflect clinical function and meet critical potency expectations, with AstraZeneca & BeOne Medicines
Future-Proof Your Analytical Toolbox
Implement chemotype-agnostic platform methods and explore advanced techniques like capillary electrophoresis to characterize "strange" conjugates and XDCs, ensuring your methods evolve with therapeutic innovation, with DebioPharm & Elixis
Tame the Transfer of Living Assays
Overcome the unique hurdles of transferring complex cell-based potency assays to QC and CDMOs with hands-on training, strategies and co-developed protocols to ensure sterile execution and reliable data, with Takeda Pharmaceutical & Sutro Biopharma
Navigate the "Case-by-Case" Regulatory Frontier
Learn to construct compelling CMC narratives and apply fit-for-purpose justifications for novel ADC attributes, transforming complex data into a clear story of product control to accelerate submissions, with AbbVie & Johnson & Johnson
Work Smarter Together: Align Your Team’s Expertise with the Agenda
Built for Your Analytical Experts
Leverage cutting-edge techniques for deep ADC structural analysis to move beyond basic DAR and tackle the core challenges of heterogeneity, charge variants, and stability for traditional and novel conjugate formats.
Built for Your Bioanalytical Experts
Focus on translating biological complexity into reliable, relevant bioassays that prove therapeutic function, and streamlining the transfer of complex, living cell assays from development to QC.
Built for Impurity Experts
Navigate the critical frontier of impurity identification and control for novel payload-linker combinations by appling small molecule elucidation tools, like HR-MS and NMR, to identify unknown degradation products and understand their formation pathways.
Explore the Full Event Guide:
- 80+ Analytical Scientists & Quality Control Specialists
- 22+ Global Speaker Faculty
- 3 Days of Unmatched Technical Content
- The Only Event For Tackling the Unique Analytical Complexities of ADC Development
Attending Companies Include
Explore the Agenda
Gain actionable insights from expert-led sessions on advanced DAR analysis, next-gen bioassays, and impurity control
Partner With Us
Connect with 80+ ADC analytical leaders actively seeking critical analytical method development and outsourcing challenges
Join ADC Analytical Experts
Network with senior scientists and decision makers from top ADC biopharma during dedicated sessions designed to build key collaborations