Rathi Kodihal

Delve into translating biological complexity into robust, reproducible, and relevant bioassays that accurately reflect clinical function. Join this workshop to prove the functional integrity of next-generation ADCs & AOCs and meet regulatory expectations for critical quality attributes by:

• Deconstructing a complex ADC & AOC mechanism of action into testable functional units, ensuring the resulting potency assay is biologically relevant and measures the activity, leading to robust, meaningful potency methods
• Selecting and engineering of reproducible cell lines, focusing on promoter strength and banking strategies, to create a stable foundation that minimizes bioassay variability and ensures consistent, reliable potency data
• Designing bioassays for bispecific and dual-payload ADCs & AOCs to address the critical challenge of proving dual-target engagement, controlling complex modalities, and demonstrating functional integrity