Scott Baggett
Principal Scientist - Analytical Chemistry Sutro Biopharma
Seminars
Wednesday 29th April 2026
Leveraging Small Molecule Elucidation Tools for ADC Payloads for Improved Payload Degradation Detection
2:30 pm
- Apply high-resolution mass spectrometry and MS/MS fragmentation to payload degradation products, to propose potential structures for novel species, enabling proactive identification and risk assessment of new impurities
- Leverage NMR spectroscopy for definitive structural elucidation, to unambiguously identify the chemical structure of major degradation products, providing the highest level of confidence for regulatory filings and understanding structure-activity relationships
- Utilize software tools designed for small molecule structure elucidation, to automate data analysis and hypothesis generation, accelerating the identification process and bridging the analytical gap
