Zhengqi Zhang
Associate Principal Scientist Merck & Co
Seminars
Wednesday 29th April 2026
Development of High-throughput SEC-MS Methods for Real-time Monitoring of the ADC Conjugation Process
12:00 pm
- Developed a high‑throughput SEC‑MS workflow enabling real‑time monitoring of reduction and conjugation kinetics during cysteine‑based ADC manufacturing, with <2 min analysis time per sample.
- Enabled rapid optimization of critical process parameters, including reductant concentration, pH, and drug‑linker ratio, while providing mechanistic insight into ADC reaction kinetics.
- Supports PAT‑enabled advanced process control, accelerating ADC development and improving manufacturing robustness.
