Control Strategies for Impurities in Linker Drug Based on Conjugatability
Time: 9:30 am
day: Day One
Details:
- Determining a control strategy for impurities in the drug-linker intermediate
- Considering whether these impurities can conjugate to the antibody intermediate
- Addressing the gap in the literature on how to determine impurity conjugatability in a systematic and tiered-based approach beyond the presence of the intact conjugation motif in the impurity
- Establishing a strategy using our in-house drug-linker intermediate, first via high resolution MS/MS
