Roundtable Discussion – Reviewing the Current Analytical Methods for DAR Distribution Assessment – Determining the Value in Use of Different Assays
Time: 11:30 am
day: Day Two
Details:
- Reviewing various methods, including LC-MS, SEC-MALS, and HIC, to assess their strengths and limitations in accurately quantifying DAR distributions in ADCs
- Discussing how different DAR distributions can influence the pharmacokinetics, efficacy, and safety of ADCs, and evaluating the importance of these findings in analytical assessments
- Exploring how to select the most appropriate DAR assessment assays based on stage of development, regulatory requirements, and the need for high-throughput or highresolution data
